Quote:
"I wanted to give the audience something new, so that started off with getting underneath the parents' story, which will unfold over probably a few movies," director Marc Webb told MTV Splash Page in a recent interview. "We don't totally wrap up that story in this first movie. It's sort of an ongoing mystery. That was something that was interesting to me."

"This is probably a reveal, but there is no wrestling match in this movie. The character is evolving in a different way. It's about finding a balance between iconic elements of the 'Spider-Man' mythology—like how Uncle Ben's death transforms him emotionally—but it happens in a different way."

"He's bitten by a spider, but maybe it's not a radioactive spider. Or maybe it is! You'll have to see. There are elements that we were very conscious of, but it all emanated from [the idea of] this kid who got left behind by his parents many, many years before. I thought that was interesting enough for me to explore."

source: http://splashpage.mtv.com/2012/04/10/amazing-spider-man-origin/